Web — there has been a resurgence in the illicit use of 2,4‐dinitrophenol by people wishing to achieve rapid weight loss. Despite its availability, the drug is banned for. However, many of these drugs are not. 2,4 dinitrophenol (dnp) is an agent reported to cause rapid weight loss, it carries a very high rate of adverse effects including death. Dnp was first used in the. A bright yellow powder is mixed with picric acid and poured into the howitzer shells headed for the western front. It’s a powerful igniting agent. Webdnp causes weight loss by increasing metabolism, or the amount of energy your body uses. Web — along with the increase of fat metabolism, the main physiological effects induced by these agents include appetite suppression, prevention of weight gain. It is extremely toxic in overdose and has a narrow therapeutic window with. Web — in 1933, an american researcher discovered that when taken by humans, dnp dramatically speeds up the metabolism leading to rapid weight loss. Web — here we summarize the human experience with dnp, the notorious weight loss agent from the 1930’s that acts as a protonophore that allows h + to leak across. Web — dnp rapidly accelerates one's basal metabolic rate, which can lead to quick weight loss. But it actually was never created to be used as a weight loss aid. Webthe drug dnp is a mitochondrial uncoupler. What is a mitochondrial uncoupler? Why might it make someone lose weight? Why is it a very dangerous drug to use?