Verkkoa community to discuss pristiq (desvenlafaxine), an antidepressant used to improve mood, feelings, and energy. The prescription medication is a serotonin. Verkkoi'm glad to read a good review of pristiq, especially after my doc suggested it as my next option if i can't tolerate lexapro. I definitely need more. Verkkoi've been on lexapro 20 mg for over a decade, mostly for anxiety. It has worked well but lately i went through a very stressful period in which my anxiety spiked (random. Verkkoa community to discuss pristiq (desvenlafaxine), an antidepressant used to improve mood, feelings, and energy. The prescription medication is a serotonin. Verkkoa community to discuss pristiq (desvenlafaxine), an antidepressant used to improve mood, feelings, and energy. The prescription medication is a serotonin. Verkkofind 1470 user ratings and reviews for pristiq oral on webmd including side effects and drug interactions, medication effectiveness, ease of use and satisfaction