Eating, diet, & nutrition. Diagnosis of primary sclerosing cholangitis. How do doctors diagnose psc? Webfind hours, address, and contact information for our locations, and schedule an appointment online. Webfinally, the diagnosis of psc can be confirmed by cholangiography. On the other hand, many experts recommend regular magnetic resonance imaging with. Webprimary sclerosing cholangitis (psc) is a chronic progressive disorder of unknown etiology that is characterized by inflammation, fibrosis, and stricturing of medium and large ducts in the intrahepatic and/or extrahepatic biliary tree.