Verkkoalso, definitely take the pristiq in the morning (i take it at 8am) and make sure you eat breakfast with it. As far as sleep goes, i would tell your doctor about your insomnia,. Verkkothe recommended dose for pristiq is 50 mg once daily, with or without food. The 50 mg dose is both a starting dose and the therapeutic dose. Verkkopristiq® (desvenlafaxine) 50 mg is the starting dose and proven effective dose. Read about dosing & administration for pristiq. See risks & benefits of pristiq. Question posted by clauds52 on 17 sep 2021. Last updated on 17 september. Verkkothe typical (average) pristiq dose is 50 milligrams (mg). The lowest dose is 25 mg, and the maximum dose is 400 mg. Keep in mind that pristiq. Verkkopristiq has a very short half life, about 12 hours, compared to other antidepressants which is why it’s important to take it at the same time every day to avoid any side. Verkkoa community to discuss pristiq (desvenlafaxine), an antidepressant used to improve mood, feelings, and energy. The prescription medication is a serotonin. Verkkoa community to discuss pristiq (desvenlafaxine), an antidepressant used to improve mood, feelings, and energy. The prescription medication is a serotonin.