Webthe registered nurse salary in illinois is $77,580 per year. This means that nurses in illinois earn an average of $37. 30 per hour. On the other hand, the national average for. Webregistered nurses in illinois earn an average of $78,260 per year or $37. 63 per hour. The percentage of u. s. Registered nurses who work in illinois is 4%. Webthis resource guide for registered nurses covers the average rn salary in illinois, pay variations, the cost of living in this state, and more. Discover the mean hourly and.