Webthis review examined the course of bipolar disorder (bd) with onset in childhood and adolescence, with a focus on persistence of symptoms, severity of illness,. Webin total, there were 177 comorbidities with a ≥ 5% prevalence. Five main clusters of comorbidities were identified. Clusters differed between ad cases and. Bipolar disorders (bds) and eating disorders (eds) are both common and severe mental illness and present wide areas of. Webhere we define the precursors (e. g. Clinical symptoms, signs or syndromes, prodromes, biomarkers) and vulnerability risk factors (e. g. Gender, family history of. Webthe concepts of pleiotropy, robustness and rewiring are central to the investigation of comorbidity and network dynamics and should be viewed together, as. Webwe use an unsupervised clustering algorithm for detecting typical disease trajectories as overlapping clusters in the multilayer comorbidity network. Our findings show that the pattern of comorbidities differed significantly among trajectory groups for late death, which could help physicians identify childhood.
