Weba positive test for ana may help determine the specific type of autoimmune disease that is affecting a patient. A negative test for ana can assist health care. Weba positive result on an ana test means that antinuclear antibodies were found in your blood. You may get a positive result if: You have sle (lupus). You have a different type. Webin most cases, a positive ana test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune.